慢性耳声中的休息状态网络:大理石和视觉区域之间的连接性增加
Tori Kok1, Rosemary Varley2, Chris Clark3
1Ear Institute, University College London 332 Gray's Inn Rd, London WC1X 8EE, UK.
Hearing research
|October 22, 2024
概括
耳患者表现出大脑连接的改变,特别是在丘脑和视觉皮层之间的功能连接增加. 这项研究没有发现静止状态网络或背侧前额叶皮层连接的差异.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 听觉神经科学 听觉神经科学
背景情况:
- 耳与中枢神经系统的异常活动有关.
- 之前的休息状态fMRI研究显示了 tinnitus 患者的神经活动的变化,但这些发现缺乏复制.
- 脊侧前额叶皮层 (DLPFC) 参与了耳困扰,是跨直流刺激 (tDCS) 的目标.
研究的目的:
- 研究与对照组相比,声患者的八个常见静止状态网络 (RSN) 的变化.
- 在耳中检查功能连接 (FC) 与背侧前额皮层 (DLPFC).
- 用休息状态功能磁共振成像 (fMRI) 扩展之前关于 tinnitus 中神经活动的发现.
主要方法:
- 休息状态的fMRI被用来比较46名耳患者与36名年龄,性别和教育匹配的对照.
- 分析了8个RSN:听觉,默认模式,感觉运动,视觉,突出,背部注意力,前对对面和语言网络.
- 专门研究了与背侧前额皮层 (DLPFC) 的功能连接 (FC).
主要成果:
- 与对照人群相比,耳患者在双边丘脑和右视觉关联皮层之间表现出功能连接 (FC) 的增加.
- 在研究的静止状态网络 (RSN) 中,在组之间没有发现FC的显著差异.
- 在耳患者和对照人群之间没有观察到涉及脊侧前额皮层 (DLPFC) 的FC差异.
结论:
- 这项研究确定了耳患者的头部视觉通路连接的特定变化.
- 与之前的一些研究相反,这项研究没有发现主要静止状态网络或DLPFC连接在耳中的广泛变化.
- 这些发现强调了在耳研究中复制的必要性,并表明了特定的连接变化而不是全球网络中断.
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