肠道脂肪酸结合蛋白作为死性肠球炎发病率和严重程度的标记:一个范围审查
Lourenço Sbragia1, Igor José Nogueira Gualberto2, Jason Xia3
1Division of Pediatric Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Sao Paulo, Brazil; Center for Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio.
The Journal of surgical research
|October 22, 2024
概括
肠脂肪酸结合蛋白 (I-FABP) 显示出作为死性肠球炎 (NEC) 的标记物具有前途,特别是在第二和第三阶段. 需要进一步的研究来澄清其在早期诊断和查中的作用.
科学领域:
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
- 生物标志物研究 生物标志物研究
背景情况:
- 死性肠球炎 (NEC) 是新生儿的一种关键性胃肠道疾病.
- 肠道脂肪酸结合蛋白 (I-FABP) 是NEC中肠道损伤的潜在指标.
研究的目的:
- 在NEC中对I-FABP进行文献范围审查.
- 确定研究缺口,并激发未来关于I-FABP作为NEC标记物的研究.
主要方法:
- 在主要数据库 (PubMed,Embase,SCOPUS,Web of Science) 搜索相关出版物.
- 使用的关键词:"死性肠球炎"",肠脂肪酸结合蛋白"",NEC"和"I-FABP".
- 接下来是PRISMA扩展范围审查 (PRISMA-S) 的指导方针.
主要成果:
- 确定了61个相关的物品.
- 将研究分类为临床 (47) 和实验 (14) 组.
结论:
- I-FABP显示了作为NEC生物标志物的潜力,特别是2和3阶段.
- 尿中的I-FABP水平与血清和血水平相关.
- 需要进一步研究I-FABP在早期诊断,差异诊断和外科NEC查中的作用.
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