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聚二甲基西洛 (PDMS) 的双重表面修饰与抗素-氨酸复合物 (ATH) 和组织等离子素激活剂 (t-PA) 增强抗瘤活性

Siyuan Li¹, Helen M Atkinson², Gerhard Fusch³

¹School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.

Biomaterials advances

|October 22, 2024

概括

这项研究通过双重表面修饰来增强接触血液的医疗器械材料. 结合抗凝剂和凝块溶解剂可以改善血液兼容性,降低血栓风险.

科学领域:

生物材料科学生物材料科学
表面化学表面化学
医疗设备工程医疗设备工程

背景情况:

与血液相互作用的医疗器械可能会由于凝血和血小板激活而导致血栓形成.
目前的全身抗凝剂和抗血小板剂增加出血风险.
表面修饰提供了一种替代策略,以改善血液兼容性.

研究的目的:

研究聚二甲基 (PDMS) 与抗血素-氨酸复合物 (ATH) 和组织等离子体激活剂 (t-PA) 的双重表面修饰.
评估使用聚多巴胺 (PDA) 作为生物的ATH和t-PA的不同固定方法.
评估联合抗凝剂和血栓溶解剂表面修饰对血液兼容性的协同效应.

主要方法:

用ATH和t-PA对PDMS进行双重表面修改,使用顺序和同时固定化技术.
使用聚多巴胺 (PDA) 涂层来增强修饰剂的附着性.
分析了表面特性 (水友性,粗性,修饰剂密度,稳定性) 和血凝结时间.

主要成果:

表面的特性,如水友性和粗性,随着修改程度的增加而增加.
修改过程显著影响了修改器密度和血稳定性.
序列修改 (t-PA然后ATH) 增强了肝素的活性.
联合ATH和t-PA显示出协同作用的抗凝剂和凝血溶解效应.

结论:

用ATH和t-PA对PDMS的双表面修饰显示出改善血液兼容性的承诺.
协同作用增强了抗凝剂和凝块溶解活动.
一般的PDA涂层策略适用于各种接触血液的材料,为医疗器械改进提供了广泛的潜力.

关键词:

抗血素肝素复合体是一种复杂的抗血素.它具有抗血栓活性.聚多巴胺胺是一种多多巴胺.蛋白质固定运动表面的修改是表面的修改.组织等离子素激活剂

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