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Updated: Jun 9, 2025

Analysis of Cell Cycle Position in Mammalian Cells
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在非典型的形形瘤中,RRM2抑制通过ATM/Rb/E2F1通路改变细胞周期

Le Hien Giang1, Kuo-Sheng Wu2, Wei-Chung Lee3

  • 1International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Department of Biology and Genetics, Hai Phong University of Medicine and Pharmacy, Hai Phong 180000, Vietnam.

Neoplasia (New York, N.Y.)
|October 22, 2024
PubMed
概括

用COH29向核糖核酸还原酶调节子单元M2 (RRM2) 诱导DNA损伤和细胞循环停止在非典型的形形瘤 (ATRT). 这种RRM2抑制会影响ATM/Rb/E2F1通路,提供一种潜在的新的ATRT治疗.

关键词:
美国ATM/Rb/E2F1这就是为什么我们会这样做.而COH29则是因为COH29而产生.细胞循环的细胞周期在RRM2中使用RRM2.

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