相关实验视频
Updated: Jun 9, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
383
[食道癌:预防和治疗的新进展]
Annegrit Decker1, Michael Quante1
1Klinik für Innere Medizin II - Gastroenterologie, Hepatologie, Endokrinologie und Infektiologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Deutsche medizinische Wochenschrift (1946)
|October 22, 2024
概括
预防食道癌症包括管理诸如肥胖和反流等危险因素. 现在先进的治疗方法包括针对性疗法和基于特定瘤标记物的免疫检查点抑制剂.
科学领域:
- 胃肠道学和瘤学
- 癌症的预防和治疗
背景情况:
- 食道癌呈现为状细胞癌和腺癌,因病因和治疗不同.
- 腺癌发病率的上升与肥胖和胃食道逆流有关,这凸显了预防的必要性.
- 目前德国的指导方针不建议进行一般的内镜查,但对于巴雷特基质增生症 (Barrett's metaplasia) 进行.
研究的目的:
- 审查目前和新兴的食道癌预防,监测和治疗策略.
- 强调早期和高级阶段不断发展的治疗景观.
- 通过生物标志物驱动疗法强调个性化医学的重要性.
主要方法:
- 关于食道癌发病,风险因素和管理的当前文献的综述.
- 对诊断和治疗策略的分析,包括内镜监测和切除.
- 检查系统性治疗的进展,包括化疗,免疫疗法和向疗法.
主要成果:
- 风险因素的修改是预防食道腺癌的关键.
- 对高风险个体来说,内镜监测至关重要,需要改进预测模型.
- 放射化疗对状细胞癌至关重要,而外科手术期间的化疗对腺癌很重要.
- 免疫检查点抑制剂 (PD-L1,MSI状态) 和向疗法 (Her2,PD1,claudin 18.2) 扩大了晚期疾病的治疗选择.
结论:
- 对食道癌的有效预防策略需要解决可修改的风险因素.
- 由生物标志物指导的个性化治疗方法正在改变食道癌的管理.
- 系统疗法的进步为晚期食道癌患者提供了新的希望,改善了辅助和息环境中的结果.
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
112
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
112
Barrett Esophagus-I: Introduction
70
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
70
Esophageal Strictures-II: Clinical Features and Management
51
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
51
Gastroesophageal Reflux Disease II: Clinical Features and Management
55
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
55
Esophageal Strictures-I: Introduction
66
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
66
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K

