前极皮层周神经网络表达和社会行为:青少年间歇性乙醇暴露的影响
Trevor T Towner1, Harper J Coleman1, Matthew A Goyden1
1Neurobiology of Adolescent Drinking in Adulthood Consortium, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY, 13902-6000, USA.
Neuropharmacology
|October 22, 2024
概括
青少年间歇性乙醇暴露会增加雄性大鼠前皮质中的围神经网络 (PNN),从而导致社会缺陷. 这突出了PNN作为乙醇引起的社会损害的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 成研究 研究成研究
背景情况:
- 青少年间歇性乙醇 (AIE) 暴露会导致社会赤字.
- 在前临皮质 (PrL) 中的帕瓦尔胺 (PV) 内神经元调节社会行为.
- 周神经网络 (PNN) 确保并调节PrL中的PV内部神经元.
研究的目的:
- 调查AIE对PrL PNN表达的影响.
- 确定PNN变化是否有助于AIE引发的社会赤字.
主要方法:
- 鼠 (P25-45) 每天通过食接受乙醇或水.
- 评估了神经元激活 (β-galactosidase) 和PNN水平.
- 冠状腺酶ABC (ChABC) 用于操纵PNN暴露后.
主要成果:
- 在成年男性中,AIE增加了PrLPN,但在暴露后立即降低了它们.
- 在暴露于AIE的女性中,PNN附近的膀性谷氨酸和GABA载体减少.
- 在男性中,CHABC治疗导致PNN上调和社会障碍.
结论:
- 在雄性大鼠中,AIE暴露可提高PrL PNNs的调节.
- 增加的PrL PNN可能会调解AIE引起的社会损害.
- 青少年酒精使用障碍的PNN是潜在的治疗目标.
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