1型糖尿病中白质过强度的量化及其与神经病变及其临床特征的关系
Tine M Hansen1, Suganthiya S Croosu2, Shahram Kianimehr3
1Department of Radiology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark; Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Selma Lagerlöfs Vej 249, 9260 Gistrup, Denmark.
Brain research
|October 22, 2024
概括
1型糖尿病与更多的周周结膜白质过强度 (WMHs) 相关,与神经病变的严重程度和神经退行有关. 深层WMH没有差异,这表明神经退行,不仅仅是缺血,也会影响糖尿病患者的大脑衰老.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 1型糖尿病 (T1D) 与神经系统并发症有关,包括外围神经病变.
- 白质超强度 (WMHs) 在衰老和脑血管疾病中很常见,但它们在T1D神经病变中的作用不明.
研究的目的:
- 量化T1D和不同神经病变表型的成年人中周周结节和深层WMHs.
- 为了将WMH负担与与糖尿病相关的因素相关联,包括神经病变严重程度和神经退行症标志物.
主要方法:
- 对56名患有T1D的大脑MRI扫描进行了分析 (子组:痛苦的DPN,无痛的DPN,没有DPN) 和20个对照组.
- 用Fazekas尺度和自动细分来评估WMH.
- 鉴定了神经病变的表型,并检查了与WMH体积,认知功能和大脑测量的相关性.
主要成果:
- 糖尿病和对照组之间在Fazekas评估的WMH中没有显著差异.
- 自动分析显示,周周结节或深层WMHs的数量没有显著差异.
- 在糖尿病组中发现,周周结膜WMH的负担较高,与DPN严重程度,年龄增加,认知能力下降以及大脑体积/新陈代谢减少有关.
结论:
- 在T1D中增加的周周结膜WMH负担与糖尿病外周神经病变 (DPN) 严重程度和神经退行症标志物有关.
- 深度WMH通常与缺血有关,没有显著差异.
- 神经退行和加速的大脑衰老可能是T1D中观察到的中央和外围神经病变的关键因素.
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