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在核中对放射素酸化的操纵accumbens核心调节风险的选择行为

Myung Ji Kwak¹, Su Jeong Choi², Wen Ting Cai³

¹Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Department of Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Progress in neurobiology

|October 22, 2024

概括

激素是一种影响细胞结构的蛋白质,当其活性在细胞核中被修改时,会改变冒险行为. 这通过改变突触功能和脊柱形态来影响决策.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
行为科学行为科学

背景情况:

埃兹林 - 素 - 素 (ERM) 蛋白质对于行为动力学和细胞形态学至关重要.
它们在核 (NAcc) 中的特定作用及其与风险回报决策的关系在很大程度上仍未被探索.

研究的目的:

研究在风险回报决策过程中NAcc核心中放射素酸化的作用.
为了检查如何操纵radixin的活动影响突触可塑性和行为在老鼠博任务 (rGT).

主要方法:

使用电生理学测量了NAcc中等状神经元中的激发/抑制 (E/I) 比率.
使用了一种相仿伪活性突变形式的激素 (Rdx-T564D),通过手术将其引入NAcc核心.
在执行rGT的老鼠中评估脊柱头大小和风险选择行为.

主要成果:

与寻求风险的老鼠相比,不愿冒险的老鼠的基础E/I比率更高.
Rdx-T564D表达减少了不愿冒险的老鼠的E/I比率,模仿了寻求风险的老鼠.
风险厌恶性老鼠的脊柱头大小和风险选择行为被Rdx-T564D改变,类似于寻求风险的老鼠.

结论:

在NAcc核心中的放射素酸化状态显著影响着谷氨酸突触传递和脊柱结构.
对激素活性的操纵直接影响rGT中的风险偏好和选择行为.
在NAcc核心中的激素是个人的风险偏好的一个关键决定因素.

关键词:

决策方式决策方式树突性脊柱树突性脊柱核积累的中心 (nucleus accumbens).雷迪克辛 (Radixin) 是一种激素.鼠博任务鼠博任务

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