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基金属有机框架:一种高效的主动和被动向纳米载体,用于抗癌性多克索鲁比药物输送

Sima Darvishi¹, Hossein Hosseinzadeh², Fahimeh Kazeminava³

¹Department of Chemistry, School of Physic and Chemistry, Alzahra University, PO Box 1993891176, Vanak, Tehran, Iran.

International journal of biological macromolecules

|October 22, 2024

概括

这项研究介绍了Cu-MOF/Hep,这是一种新的药物输送系统,结合了基于铜的金属有机框架和氨酸,用于向癌症治疗. 它表现出pH受控释放和对癌细胞的增强疗效.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

开发有效的药物输送系统 (DDS) 对向癌症治疗至关重要.
金属有机框架 (MOF) 为药物封装和释放提供了独特的特性.
肝素 (Hep) 可以通过受体相互作用促进活性向.

研究的目的:

通过将基于Cu的MOF与肝素结合起来,创建一个新的DDS,Cu-MOF/Hep.
为了实现pH控制的药物释放以提高治疗疗效.
评估DDS的主动和被动准能力和抗癌作用.

主要方法:

使用FT-IR,XRD,SEM,EDX,TEM,DLS和TGA等技术合成和描述Cu-MOF/Hep.
在不同pH值 (5和7.4) 下对多克索鲁比 (DOX) 的加载和释放进行体外研究.
对MCF-7细胞的细胞毒性评估和亡率的评估.

主要成果:

通过全面的表征证实了Cu-MOF/Hep的成功合成.
在pH值5 (>90%) 与pH值7.4 (<10%) 相比,DOX的释放显著增加,模仿瘤微环境条件.
证明了显著的细胞毒性对MCF-7细胞与增强的亡诱导,表明通过CD44受体有效向.

结论:

Cu-MOF/Hep是一种有前途的DDS,具有pH控制的释放和增强的抗癌功效.
MOF和肝素的组合为向药物输送提供了一个可行的平台.
这个系统显示出开发先进的抗癌治疗策略的潜力.

关键词:

德克索鲁比辛是一种多克索鲁比辛.药物交付是药物交付的过程.肝素是一种肝素.金属有机框架的框架.接收器接收器接收器

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