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单核酸多态和运动员肌/关节损伤:系统性审查和元分析

Yumi Fukuyama^1,2, Haruka Murakami², Motoyuki Iemitsu²

¹Department of Physical Therapy, Aino University, Ibaraki, Japan.

International journal of sports medicine

|October 22, 2024

概括

遗传变异影响运动员受伤风险. 血管内皮生长因子A (VEGFA) rs699947多态性与运动员肌和带损伤风险降低有关.

科学领域:

运动医学运动医学
遗传学遗传学是一个
整形外科整形外科整形外科

背景情况:

肌和带损伤在运动员中很常见.
遗传因素可能会使运动员易受这些伤害.

研究的目的:

调查运动员遗传多态和肌/带损伤之间的关联.
识别增加或减少受伤风险的特定遗传变异.

主要方法:

基因研究的系统审查和元分析.
搜索了多个数据库,直到2023年7月.
包括31篇文章 (1687次受伤,2227次对照),对12篇文章进行了元分析.

主要成果:

确定了144个候选基因多态.
血管内皮生长因子A (VEGFA) rs699947多态性显示,C等位基因的损伤风险较低 (OR=0.80,p=0.03).
其他分析的多态性并没有显著影响受伤风险.

结论:

VEGFA rs699947多态性与运动员肌和带损伤风险有关.
这一发现有助于了解运动伤害的遗传风险因素.

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