在前性队列研究中,饮食豆类亚型和2型糖尿病之间的性别特定关联
Hye Won Woo1,2, Sangmo Hong3, Min-Ho Shin4
1Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
Epidemiology and health
|October 22, 2024
概括
豆类消费,特别是非大豆品种,可能会降低两性2型糖尿病的风险. 豆摄入量仅在女性身上表现出保护作用,突显了糖尿病预防的性别特异性饮食益处.
科学领域:
- 营养流行病学 营养流行病学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 饮食中的植物雌激素,特别是来自大豆的植物雌激素,被假设以性别特定的方式影响2型糖尿病风险.
- 有限的研究存在于各种豆类亚型 (大豆,豆类,花生) 与2型糖尿病发病率的性别特定关联.
- 遗传因素可能会调节豆类消费与2型糖尿病风险之间的关系.
研究的目的:
- 调查习惯性大豆和非大豆豆类豆类消费与2型糖尿病发病率的前景性相关性.
- 探索影响这些关联的潜在的性别特异性遗传相互作用.
主要方法:
- 一项前性队列研究涉及16,666名参与者,其追踪时间为96,945人年.
- 确定了发生的2型糖尿病病例 (n=945).
- 累计豆类亚型摄入量使用经过验证的食物频率调查问卷进行评估.
主要成果:
- 非大豆豆类 (豆类,花生) 与男性和女性的2型糖尿病风险相反相关.
- 饮食中的大豆摄入量与女性的2型糖尿病风险有显著的反向关联 (IRR,0.66;95% CI,0.48-0.80).
- 对于大豆而言,这种性别特异性关联是由LRRTM4和GFPT2.2中的遗传变异调节的.
结论:
- 习惯性豆类消费提供了对2型糖尿病的保护作用,益处因性别而异.
- 非大豆豆类似乎对预防2型糖尿病具有普遍的益处.
- 豆类消费可能对女性的2型糖尿病预防特别有益,可能受到遗传因素的影响.
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