尿动力学膀顺应性和尿路纤维化标志物之间的关系在患有神经性膀功能障碍的儿童中
Deniz Uğurlu1, Arzu Canmemiş2, Ferruh Kemal İşman3
1İstanbul Medeniyet University Faculty of Medicine Department of Pediatric Surgery, İstanbul, Turkey.
Journal of pediatric urology
|October 22, 2024
概括
在患有神经性膀功能障碍 (NBD) 的儿童中,尿液中的原蛋白水平可能表明膀纤维化和膀服从性降低. 这些标志物显示出未来对膀符合性进行非侵入性评估的潜力.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
- 儿科 儿科 儿科
背景情况:
- 在神经性膀功能障碍 (NBD) 中,膀遵守度降低会增加上泌尿道风险.
- 尿动力学是评估膀符合规定的标准.
研究的目的:
- 在NBD患者中探索低膀合规性和尿纤维化标志物之间的联系.
- 调查尿原1型和尿原3型作为膀纤维化的潜在指标.
主要方法:
- 对比了具有低合规性 (LC),正常合规性 (NC) 和对照性 (C) 的脊柱裂患者.
- 使用ELISA测量了尿原蛋白1型,原蛋白3型和血清原蛋白水平.
- 使用公式 ΔV/ΔP 计算出膀的符合性 (低符合性<15毫升/厘米H2O).
主要成果:
- 与对照组相比,LC组中的1型尿和3型公原显著高于对照组.
- 尿中的1型原蛋白水平超过9.20ng/ml显示了80.6%的灵敏度和70.6%的特异性.
- 尿中三型原蛋白水平超过78ng/ml,显示敏感度为87%,特异性为70.6%,符合性较低.
结论:
- 尿中的原蛋白水平可以作为NBD中膀壁纤维化的一种生化标志物.
- 这些尿道纤维化标志物显示出未来对膀符合性的非侵入性评估的潜力,可能减少对尿动力学的依赖.
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