治疗性手术后直肠癌局部复发的危险因素:单中心回顾性研究
Floryn Cherbanyk1, Marie Burgard2, Lucien Widmer3
1Department of Surgery, HFR Fribourg-Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland; University of Fribourg, Av. de l'Europe 20, 1700 Fribourg, Switzerland.
Journal of visceral surgery
|October 22, 2024
概括
在直肠癌手术后局部复发与差异化瘤和阳性环切除边缘 (CRM) 有关. 在这项研究中,瘤位置不是一个重要的因素.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道手术 胃肠道手术
背景情况:
- 局部复发影响了大约7%的直肠癌患者在治疗性手术后5年内.
- 阳性环切除边缘 (CRM) 是局部复发的重要风险因素.
- 瘤组织病理学,静脉漏,远端边缘状态和瘤局部也被报告为危险因素.
研究的目的:
- 评估直肠癌患者局部复发的风险因素.
- 调查瘤局部 (前部与后部) 作为局部复发的独立预测因素.
- 评估CRM和瘤分化对局部复发率的影响.
主要方法:
- 对128名患有II或III期直肠癌的患者进行了回顾性队列研究 (2007-2018).
- 患者接受了新辅助化疗和放射治疗,随后进行了外科切除,并切除了完全的甲骨干.
- 风险因素,包括通过成像评估的瘤局部,使用单变量和多变量回归分析.
主要成果:
- 5年的局部复发率为7%.
- 差异化瘤组织学和阳性CRM独立与局部复发相关 (P=0.001两者).
- 瘤局部 (前部或后部) 并不是与局部复发相关的统计学上显著因素.
结论:
- 阳性CRM和差异化瘤组织学是直肠癌局部复发的独立风险因素.
- 在这个患者队列中,先前的瘤定位并未被确定为独立的风险因素.
- 研究结果强调了边缘状况和瘤生物学在预测局部复发中的重要性.
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