由Exophiala dermatitidis引起的被忽视的肺部感染错误地被识别为Rhodotorula spp
Daichi Setoguchi1,2, Naoki Iwanaga1, Yuya Ito1
1Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Mycoses
|October 22, 2024
概括
黑色真菌Exophiala dermatitidis可以引起肺部感染,并被误认为是Rhodotorula spp. 基因鉴定对于诊断E.皮肤炎至关重要,特别是在患有慢性肺部疾病的患者中.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 一种新兴的黑色真菌Exophiala dermatitidis会导致肺部感染.
- 传统的培养方法可能会低估E. dermatitidis感染.
- 错误地将E. dermatitidis识别为Rhodotorula spp. 这是一种错误的识别. 可以发生在商业套件中.
研究的目的:
- 为了调查Exophiala dermatitidis的流行情况,错误地识别为Rhodotorula spp.
- 评估E.皮肤炎在肺部感染中的临床意义.
- 突出在呼吸器样本中准确识别真菌的重要性.
主要方法:
- 使用内部转录的间隔基因和大亚单元RNA基因 (D1/D2区域) 的遗传鉴定.
- 对11名怀疑患有E. dermatitidis肺部感染的患者进行了回顾性临床数据审查.
- 对并发病的分析,包括慢性肺阿斯伯吉洛症 (CPA) 和非结核性菌根菌 (NTM) 感染.
主要成果:
- 在43个Rhodotorula spp.中的22个. 分离物被遗传鉴定为E. dermatitidis.
- 11例肺部感染与E. dermatitidis有关,其中5例确诊,6例可能.
- 相关疾病包括CPA,NTM感染和肺无心病,这表明了联合检测的趋势.
结论:
- 应考虑在Rhodotorula spp.时使用E.皮肤炎. 是从气道标本中分离出来的.
- 准确识别E.皮肤炎对于治疗慢性肺部感染很重要.
- 这项研究强调了传统方法的局限性和分子技术的必要性,用于真菌诊断.
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