截肢导致的动脉系统改变对动脉硬性和血液动力学的影响:一个数值研究
Hasan Obeid1,2, Vasiliki Bikia3,4, Patrick Segers5
1CHU de Québec Research Center-L'Hôtel-Dieu de Québec Hospital, 11, Côte du Palais, Québec City, QC, G1R 2J6, Canada.
Scientific reports
|October 22, 2024
概括
下肢截肢通过改变动脉生物力学增加了心血管风险. 模拟显示动脉硬度和血压增加,特别是在腹部大动脉,导致心脏风险更高.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 计算生物学 计算生物学
背景情况:
- 下肢截肢的受试者面临心血管死亡率和发病率的风险增加.
- 截肢可能会引起动脉树的改变,影响生物力学,血压和血流,可能会加剧心血管风险.
研究的目的:
- 通过计算机模拟模型研究截肢对动脉生物力学和血液动力学的纯机械影响.
- 评估截肢的不同程度如何影响动脉硬,血压和血液流动特征.
主要方法:
- 采用了详细的一维 (1D) 动脉网络模型 (143个段) 与零维 (0D) 左心室模型相结合.
- 对五种动脉网络设置进行了模拟:四肢控制,单边,双边,三边和四边截肢场景.
- 分析包括区域度 (脉冲波速度),血压,血流,脉冲压放大,波分离和波强度.
主要成果:
- 中型和小型动脉的硬度增加,截肢的严重程度更大,而大动脉的硬度保持不变.
- 尽管心脏输出量下降,但静脉压和静脉压升高,使中心和外围脉冲压升高.
- 缩压的峰值和缩血流的峰值变化在腹腔大动脉中最明显. 波强度分析表明心脏血液动力学负荷发生变化,截肢时间延长.
结论:
- 截肢引起的动脉网络几何和生物力学变化可以显著影响心血管血动力学.
- 这些生物力学和血液力学变化可能与其他危险因素相互作用,导致截肢者的心血管风险增加.
- 模拟建模为截肢对心血管系统的机械后果提供了宝贵的见解.
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