生物衰老调解了挥发性有机化合物和心血管疾病之间的关联
Qingqing Cao1, Yu Song1, Changsheng Huan1
1Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China.
BMC public health
|October 22, 2024
概括
暴露于挥发性有机化合物 (VOC) 会增加心血管疾病 (CVD) 的风险. 生物衰老 (BA) 调解了这种关联,突出了心血管疾病发展的潜在机制.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 衰老科学 衰老科学
背景情况:
- 关于挥发性有机化合物 (VOC) 与心血管疾病 (CVD) 之间的联系的证据有限.
- 在这种关系中,生物衰老 (BA) 的调解作用仍然未被研究.
- 了解这些关联对于公共卫生和疾病预防战略至关重要.
研究的目的:
- 调查个人和联合VOC暴露与心血管疾病风险之间的关联.
- 探索生物衰老 (BA) 在VOC和CVD之间的关系中的潜在调解作用.
- 确定有助于心脏病风险的特定VOC和BA指标.
主要方法:
- 使用后勤回归模型来评估VOCs (mVOCs),BA和CVD的代谢物之间的关系.
- 使用权重量子素总和 (WQS) 回归和自适应弹性网络 (AENET-ERS) 来评估混合VOCs对心脏病的同时暴露影响.
- 进行中介分析以量化BA在VOCs-CVD途径中的作用.
主要成果:
- 像CYMA这样的单个VOC显示心血管疾病风险增加. WQS回归表明mVOC混合物与心血管疾病之间存在显著的关联 (OR=1.292).
- AENET-ERS确定了与心血管疾病相关的8种显著的mVOC,其环境风险评分 (ERS) 增加了风险 (OR=1.538).
- 三个BA指标显著调解了mVOC混合物与心血管疾病之间的关联,分别占11.32%,34.34%和7.92%的效果.
结论:
- 个人和组合的VOC暴露都与心血管疾病风险的增加有关.
- 生物衰老在暴露于VOC和心血管疾病之间的途径中起到调解作用.
- 这项研究阐明了一种潜在的生物机制,通过这种机制,环境暴露会导致心血管疾病的发展.
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