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芯片上的瘤微环境:构建和应用

Hanzheng Xu^1,2, Jiangtao Wen³, Jiahua Yang¹

¹Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Cell communication and signaling : CCS

|October 23, 2024

概括

瘤微环境芯片 (TMOC) 平台通过模拟体内瘤微环境,为研究癌症提供了一种新的方法. 进一步与组织工程的整合可以创建更好的临床前癌症模型.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
微流体学微流体学

背景情况:

癌症仍然是全球首要的死亡原因,治疗疗效受到瘤异质性和当前模型无法复制人类瘤微环境的限制.
瘤发生和生理复杂性的不明确分子机制进一步阻碍了有效的癌症治疗方法的开发.

研究的目的:

审查癌症研究瘤微环境芯片 (TMOC) 平台的进展.
在不同癌症模型中探索各种TMOC类型的应用.
讨论TMOC作为一种精细的临床前癌症模型的未来潜力.

主要方法:

三维细胞培养与微流体系统的整合,以创建TMOC平台.
在体内瘤微环境的关键组件和生理特征的模拟.
审查有关TMOC进步和应用的现有文献.

主要成果:

TMOC平台提供了一个动态的体外系统,模仿瘤微环境,使得瘤进展的研究.
不同的TMOC设计已经开发并应用于各种癌症类型.
目前的TMOC平台显示了促进癌症研究的前景.

结论:

在模拟瘤微环境进行研究方面,TMOC技术是迈出了重要的一步.
加强与组织工程和微生理系统的整合对于将TMOC发展为更精细的临床前模型至关重要.
TMOC平台有可能在了解和治疗癌症方面取得突破.

关键词:

癌症建模的模型.在体外模型模型.微流体学微流体学瘤芯片是一个瘤芯片.瘤微环境是一个微环境.

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