交付策略,以改善猪暴露于口服抗菌素
Noslen Hernández1, Béatrice B Roques1,2, Marlène Z Lacroix1,2
1Université de Toulouse, INRAE, UR InTheres, 23, chemin des Capelles, Toulouse, France.
BMC veterinary research
|October 23, 2024
概括
根据猪饮用模式量身定制抗微生物药物,可以改善药物分配和动物暴露. 这种策略可以提高药物的有效性,并打击抗菌素耐药性,而不会增加药物的总剂量.
科学领域:
- 兽医药理学 兽医药理学
- 动物养殖 动物养殖
- 药理动力学 药理动力学
背景情况:
- 通过牲畜饮用水输送抗微生物药物会导致可变的暴露,危及疾病和耐药性.
- 变化源于药物度波动,动物饮酒行为和个体的药理动力学.
- 优化药物输送对于有效的疾病控制和抗菌药物管理至关重要.
研究的目的:
- 根据猪的饮酒习惯,制定和评估一项针对猪适应抗菌剂的策略.
- 为了改善药物分发和动物暴露,而不会增加总体抗菌剂量.
- 为了减轻与牲畜可变药物暴露相关的风险.
主要方法:
- 开发和评估基于猪个体饮酒行为的分销策略.
- 分析基于水的药物输送的各种优化标准.
- 使用药理动力学/药理动力学 (PK/PD) 建模来评估暴露.
主要成果:
- 基于饮酒行为的几种策略有效地增加了动物的整体暴露.
- 确定了提高暴露不足的动物的暴露,提高平均暴露或最大限度地增加大多数动物的暴露的策略.
- 优化特定的标准是构建有效的基于水的分配策略的关键.
结论:
- 将饮酒行为纳入阿莫西西林输送中显著增加了猪仔达到目标AUC/MIC比率.
- 对于Pasteurella multocida,实现目标的小猪的百分比从30%增加到至少60%.
- 对于Actinobacillus pleuropneumoniae,这一百分比从20%增加到70%以上.
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