高级糖化最终产品的血清溶解受体可以预测微观多炎和多炎粒状瘤的死亡率
Taejun Yoon1, Sung Soo Ahn2, Jang Woo Ha3
1Department of Medical Science, BK21 Plus Project, Yonsei University College of Medicine, Seoul, Korea.
Yonsei medical journal
|October 23, 2024
概括
诊断时的血清可溶性RAGE (sRAGE) 水平预测了微观多炎 (MPA) 和多炎粒状炎 (GPA) 患者的死亡率. 较低的sRAGE表明这些血管炎患者的死亡风险更高.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床生物标志物 临床生物标志物
背景情况:
- 微观多叶膜炎 (MPA) 和带多叶膜炎的颗粒瘤 (GPA) 是严重的自身免疫性疾病.
- 识别可靠的预后标志物对于管理这些疾病至关重要.
研究的目的:
- 为了确定是否血清细胞外新发现的高级糖化终端产品结合蛋白 (EN-RAGE) 的受体和诊断时RAGE的可溶性形式 (sRAGE) 预测MPA和GPA患者的全因死亡率.
- 研究这些生物标志物对死亡率的独立预测价值.
主要方法:
- 血清EN-RAGE和sRAGE水平测定在75名以前没有接受过治疗的MPA和GPA患者中.
- 通过灵敏度和特异性分析确定了最佳截止值.
- 使用多变量Cox比例危险回归模型来评估死亡率的独立预测因素.
主要成果:
- 无论是EN-RAGE还是sRAGE都与疾病活动得分 (伯明翰血管炎活动得分) 没有相关性.
- 死亡的患者在诊断时血清EN-RAGE显著降低,血清sRAGE较高.
- 诊断时血清血清率≥1.82 ng/mL独立地与全因死亡风险增加7.094倍有关.
结论:
- 诊断时的血清sRAGE是MPA和GPA患者全因死亡率的重要独立预测指标.
- 这一发现为血管炎患者的风险分层和个性化管理提供了潜在的工具.
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