揭示无形的细胞外囊泡:用于其体内可视化的尖端技术
Prakash Gangadaran1,2,3, Fatima Khan4, Ramya Lakshmi Rajendran2,3
1BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
|October 23, 2024
概括
了解细胞外囊泡 (EV) 在体内的行为对于它们作为theranostics的使用至关重要. 本综述探讨了先进的体内成像技术,以追踪电动汽车并改进其临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 细胞外囊泡 (EVs) 是具有治疗潜力的关键细胞间介质.
- 由于体内生物分布和药理动力学不清楚,它们作为治疗药物的临床应用受到阻碍.
- 在体内成像对于理解生物系统中的EV行为至关重要.
研究的目的:
- 审查目前用于追踪细胞外囊泡的体内成像方法.
- 评估各种电动汽车标签和成像技术的优缺点.
- 突出挑战和未来的方向,以临床翻译的基于电动汽车的theranostics.
主要方法:
- 对细胞外囊泡的最先进的体内成像技术的审查.
- 分析EV标签策略,包括光学,磁共振和核成像.
- 对每个成像模式的优点和局限性的全面探索.
主要成果:
- 现有各种标记剂和成像技术可以在体内跟踪EV.
- 每种成像方法在临床翻译中都有独特的优点和缺点.
- 了解EV指向,保留,半衰期和排泄途径至关重要.
结论:
- 在体内成像对于促进细胞外囊泡的治疗应用至关重要.
- 需要进一步的研究来克服EV成像和临床整合方面的挑战.
- 优化EV成像技术将有助于它们在天文学和医疗实践中的应用.
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