上腺素对卵巢功能障碍的影响通过介导小鼠模型中的铁亡
Hanqing Hong1,2, Chengqi Xiao1,2, Lichun Weng1,2
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Acta biochimica et biophysica Sinica
|October 23, 2024
概括
上腺素 (NE) 触发卵巢功能障碍通过铁亡,细胞死亡过程. 辅酶Q10 (CoQ10) 通过抑制铁亡,保护生殖功能,有效地逆转NE诱导的卵巢损伤.
科学领域:
- 生殖生物学和内分泌学.
- 细胞应激和死亡途径
- 药理学和治疗干预措施.
背景情况:
- 压力与卵巢功能障碍有关,其中上腺素 (NE) 起着关键作用.
- 通过NE影响卵巢功能的特定机制,特别是铁亡,尚未完全理解.
- 确定治疗策略以抵消NE诱导的卵巢损伤对于生殖健康至关重要.
研究的目的:
- 调查北上腺素 (NE) 在诱导卵巢功能障碍中的作用.
- 阐明NE诱导的卵巢损伤的潜在机制,重点是铁亡.
- 评估辅酶Q10 (CoQ10) 对NE诱导的卵巢功能障碍的潜在保护作用.
主要方法:
- 通过腹膜内注射为期 4 周,建立了一种用诺拉上腺素 (NE) 治疗的小鼠模型.
- 利用RNA测序来分析卵巢组织中的基因表达变化.
- 使用KGN颗粒细胞系进行的体外实验和使用辅酶Q10补充的体内研究.
主要成果:
- NE治疗扰乱了雌激素周期,降低了抗穆勒尔激素 (AMH) 和雌激素 (E2),增加了卵泡刺激激素 (FSH).
- NE诱导的卵巢铁亡,其特征是活性氧物种 (ROS) 的增加,铁离子,甲 (MDA) 和降低的谷氨过氧酶4 (GPX4).
- 辅酶Q10 (CoQ10) 的使用逆转了NE诱导的卵巢功能障碍和ferroptosis标志物在体外和体内.
结论:
- 上腺素 (NE) 通过促进卵巢组织中的铁亡来诱导卵巢功能障碍.
- 辅酶Q10 (CoQ10) 通过抑制NE诱导的铁亡,显示出在保护生殖功能方面具有显著的潜力.
- 向铁亡途径可能为与压力相关的生殖障碍提供新的治疗策略.
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