代谢性肥胖现象和甲状腺癌风险:对证据的系统探索
Mehdi Hedayati1, Majid Valizadeh2, Behnaz Abiri2
1Cellular and Molecular Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran.
Obesity science & practice
|October 23, 2024
概括
代谢不健康的肥胖,特别是中心脂肪,增加了甲状腺癌的风险. 代谢健康的肥胖和甲状腺癌之间的联系需要进一步调查.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肥胖是多种癌症的一个已确定的风险因素.
- 不同的代谢性肥胖表型与甲状腺癌风险之间的特定关系还没有得到很好的定义.
- 了解这些关联对于有针对性的癌症预防策略至关重要.
研究的目的:
- 系统地审查和综合有关代谢性肥胖表型与甲状腺癌风险之间的相关证据.
- 澄清不同肥胖亚型在甲状腺癌发生中的作用.
- 为临床风险评估和公共卫生干预提供信息.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在主要数据库 (PubMed,Scopus,EMBASE,Web of Science,Google Scholar) 进行全面的文献搜索,截至2024年4月.
- 包括调查代谢肥胖现型和甲状腺癌风险的队列研究.
主要成果:
- 包括5个队列研究,共有831510名参与者.
- 在代谢上不健康的肥胖表明与两性都患甲状腺癌风险升高的一致关联.
- 中部脂肪被确定为甲状腺癌风险的重要预测因素.
- 潜在的机制包括慢性炎症,荷尔蒙失调和改变的信号通路.
- 代谢健康肥胖的作用仍在争论中,一些研究表明它具有中性或保护作用.
结论:
- 代谢性肥胖现象,特别是不健康的个人资料和中心脂肪,与增加甲状腺癌风险有关.
- 代谢状态是评估甲状腺癌风险的关键因素,与一般肥胖症一起.
- 需要进一步的研究,以充分阐明新陈代谢健康肥胖的细微差别及其对甲状腺癌的影响.
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