在生物技术过程和制药中控制藻类化物 (迷你评论)
A Volnin1, A Parshikov1, N Tsybulko1
1Laboratory of Biotechnology, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia.
Frontiers in toxicology
|October 23, 2024
概括
本综述详细介绍了用于制药和生物技术中的藻类化合物的分析方法. 它涵盖了质量控制,工艺监测和开发"智能制造"技术,以实现可持续生产.
科学领域:
- 分析化学 分析化学
- 生物技术是生物技术.
- 制药科学 制药科学
背景情况:
- 在生物技术中,藻类对于菌株的发展至关重要,在药品中,对于原材料的质量控制,剂量形式和稳定性至关重要.
- 精确分析藻类化物对于理解生物合成,积累,分泌和制造过程至关重要.
研究的目的:
- 审查藻类的定性和定量化学分析方法.
- 涵盖 ergopeptines,二和衍生物以及半合成药物如卡伯戈林,内塞戈林和珀戈利德的分析方法.
- 讨论由改进的菌株和工艺分析技术 (PAT) 推动的分析策略的演变,以实现"智能制造".
主要方法:
- 对各种矩阵中的藻类化合物的分析方法的审查:平板电脑,制药形式,液体培养,菌根和硬化菌.
- 专注于对 ergopeptines 的方法,包括二和衍生物,以及半合成 ergot-derived 药物.
- 讨论包括质谱学,NMR分析,液体染色学,快速分析和电化学传感器在内的技术.
主要成果:
- 分析方法需要高的特异性来分离衍生品和epimers,较低的检测极限不那么重要.
- 质谱和NMR是关键技术,NMR的价值是准确性和特异性.
- 液体染色学和快速分析方法正在不断发展,随着日常实践的改进设备,电化学传感器显示出对实时控制的承诺.
结论:
- 藻类类的分析方法正在适应生物技术和制药制造业的进步,强调特异性和实时监测.
- 走向"智能制造"的趋势需要针对可持续发展,成本效益和质量管理制定强有力的分析策略.
- 分析技术的持续发展,包括传感器,对于精确控制藻化物生产和制药应用至关重要.
关键词:
在HPLC中使用HPLC.埃尔戈甲类化合物 埃尔戈甲类化合物埃尔戈特类化合物 埃尔戈特类化合物表达方法表达方法.高精度的高精度方法.过程分析技术 技术分析定性分析是一种定性分析.定量分析量化分析更多相关视频
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