多发性内分泌瘤1型下垂体腺瘤的长期结果:一项全国性的研究
Nuria Valdés1,2, Ana Romero3, Estrella Diego4
1Endocrinology & Nutrition Department, Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain.
Frontiers in endocrinology
|October 23, 2024
概括
与多发性内分泌新陈代谢1型 (MEN1) 相关的垂体腺瘤 (PA) 显示出进展风险较低,特别是微型PA. 建议对MEN1 PAs进行长期监测,而不是进行密集监测.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 从历史上看,与多发性内分泌新陈代谢1型 (MEN1) 相关的垂体腺瘤 (PA) 被认为比零星的PA更具侵略性.
- 最近的证据表明类似的行为,促使进一步调查长期结果和MEN1 PAs的预测因素.
研究的目的:
- 评估与MEN1相关的垂体腺瘤 (PAs) 的长期结果.
- 为了确定 MEN1 PAs 的行为和进展的预测因素.
主要方法:
- 进行了一项全国性的,多中心的,回顾性队列研究.
- 收集的数据包括患者人口统计,生殖线MEN1致病变体 (PV),PA特征,治疗方法和结果,随访时间至少为1年.
主要成果:
- 分析了84种PA;最常见的是分泌前乳素的PA (PRLomas) 和微腺瘤.
- 在8年内,微型PA向侵入性宏型PA的进展风险为7.2%,在微型PRLomas中更高的概率.
- 在瘤大小,性别,治疗持续时间或MEN1PV和进展之间没有发现显著的关联.
结论:
- 与MEN1相关的微型PAs显示出进展到侵入性宏型PAs的风险很低,不论性别,年龄或生殖系MEN1 PV.
- 素分泌的微小PAs (microPRLomas) 呈现出更高的长期进展风险.
- 建议对与MEN1相关的PA进行长期监测,并减少频率,而不是进行密集的短期监测.
关键词:
多重内分泌新陈代谢1型 1宏腺瘤是什么?宏腺瘤是什么微腺瘤是一种微腺瘤.不起作用的垂体腺瘤.结果就是结果.下垂体腺瘤是什么这是一个渐进的过程.孕产妇的乳腺癌 (prolactinomas) 是一个更多相关视频
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