用常规代谢参数预测反流性食道炎的诺米图:一项回顾性研究
Tao He1,2, Xiaoyu Sun1,2, Zhijun Duan1,2
1The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Archives of medical science : AMS
|October 23, 2024
概括
像BMI和胆固醇这样的常规代谢参数与反流性食道炎 (RE) 的患病率和严重程度有关. 使用这些因素,一个新的名ogram 准确地预测了 RE 风险.
科学领域:
- 胃肠病学 胃肠病学
- 代谢医学是一种代谢医学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 逆流性食道炎 (RE) 影响着全球人口的很大一部分.
- 识别RE流行和严重程度的风险因素对于有效管理至关重要.
- 常规代谢参数越来越多地被认为是它们在各种健康状况中的潜在作用.
研究的目的:
- 调查常规代谢参数与反流性食道炎 (RE) 的患病率和严重程度之间的关联.
- 为预测可再生能源风险开发和验证一种易于使用的诺米克图.
- 确定可再生能源的独立风险因素和预后因素.
主要方法:
- 对10881名个体上部胃肠道内镜数据的分析.
- 单变量和多变量逻辑回归以确定RE流行风险因素.
- 顺序逻辑回归用于确定RE严重性的预后因素.
- 使用ROC曲线,校准曲线,DCA和CIC分析构建和评估预测名录的性能.
主要成果:
- 43.8%的参与者已经确认了RE.
- 确定的主要危险因素包括BMI,年龄,酒精使用,糖尿病,*Helicobacter pylori*,血压,葡萄糖,脂质样本 (LDL-C,HDL-C,TG,TC),白蛋白,尿酸,FT3和FT4.
- 这种17个因素的诺姆图表表现出了出色的预测性能,AUC为0.921.
- 高血压,糖尿病和脂质样本与RE严重程度有关.
结论:
- 常规代谢参数与RE患病率和严重程度显著相关.
- 开发的名图为预测RE流行率提供了一个有价值的工具.
- 进一步的临床应用这个名图可以帮助早期检测和管理RE.
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