审查光生物调节治疗在瘤治疗中的效率
Bibhus Luitel1, Tanush Duggisani1, Anuj Luitel1
1The Ohio State University, Columbus, OH, United States.
Frontiers in oncology
|October 23, 2024
概括
光生物调节疗法 (PBMT) 在癌症治疗中显示出潜力,激光和LED应用不同影响癌细胞. 需要进一步的研究,以优化PBMT协议的安全性和有效性在临床瘤学.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 照相医疗 (photomedicine) 是一种医学.
背景情况:
- 光生物调节疗法 (PBMT) 在瘤治疗中越来越多地被探索.
- PBMT使用激光和发光二极管 (LED) 技术.
- 系统性审查对于评估新出现的治疗方式至关重要.
研究的目的:
- 系统地审查激光和LED PBMT在瘤治疗实践中的影响.
- 综合PBMT对癌细胞行为和治疗敏感性的影响的研究结果.
- 评估PBMT在管理癌症治疗副作用和改善生活质量的作用.
主要方法:
- 系统的文献审查遵循PRISMA指南.
- 包括23项研究:14项是激光PBMT,9项是LEDPBMT.
- 在体外和体外实验数据的分析.
主要成果:
- 激光PBMT在体外证明了亡诱导和增强的化学敏感性,但体内对瘤生长的影响因波长而异.
- LED PBMT (蓝光) 抑制了黑色素瘤和胰腺癌细胞生长;红光引起了人们对口腔癌侵入性的担忧.
- 激光和LED PBMT都有效地减轻了口腔粘膜炎,异位症和外围神经病变等副作用,改善了患者的生活质量.
结论:
- 在瘤学中,PBMT是一种有前途的辅助疗法,其效果因光参数和癌症类型而异.
- 优化PBMT协议对于建立长期的安全性和有效性至关重要.
- 需要精心设计的临床研究来验证PBMT在各种瘤情景中的作用.
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