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相关概念视频

Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Proteomics01:33

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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iTraNet:一个基于Web的平台,用于集成的跨电网网络可视化和分析.

Hikaru Sugimoto1, Keigo Morita2,3, Dongzi Li2

  • 1Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Bioinformatics advances
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概括
此摘要是机器生成的。

iTraNet可视化和分析转基因网络,整合基因调节,蛋白质-蛋白质相互作用和代谢数据. 这种工具揭示了野生类型和肥胖小鼠对葡萄糖的分子反应的差异.

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科学领域:

  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.
  • 计算生物学是一种计算生物学.

背景情况:

  • 了解生物系统依赖于分析各种分子网络,包括基因调节,蛋白质-蛋白质相互作用和代谢网络.
  • 由于各种数据库和复杂的分析方法,分析这些网络是复杂的.
  • 代谢网络涉及基质,产物和酶,受全调节和基因表达的影响.

研究的目的:

  • 开发一个Web应用程序,iTraNet,用于可视化和分析集成的trans-omics网络.
  • 通过网络分析,研究野生类型与肥胖 (ob/ob) 鼠对葡萄糖的分子反应的差异.

主要方法:

  • 开发iTraNet,一个集基因调控,蛋白质与蛋白质相互作用,代谢和代谢物交换网络的网络应用程序.
  • 应用iTraNet来分析来自野生类型和肥胖/肥胖小鼠的转基因数据.
  • 对网络枢纽分子对葡萄糖的反应进行比较分析.

主要成果:

  • iTraNet成功地可视化和分析集成的trans-omics网络.
  • 在野生型小鼠中,关键网络分子对葡萄糖的管理做出了反应.
  • 这种反应模式在ob/ob小鼠中不存在,这表明代谢调节发生了改变.

结论:

  • iTraNet为研究人员探索复杂的生物网络提供了一个有价值的工具.
  • 使用iTraNet的网络分析可以揭示生理反应的系统差异,例如与肥胖和葡萄糖代谢相关的.
  • 这些发现突出了肥胖分子信号通路的潜在干扰.