败血症患者体质指数与性别特定的28天死亡率之间的相关性:一项回顾性队列研究
Chong Li1, Huaping Huang2, Qingjie Xia3
1Department of Osteoporosis, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Kunshan, China.
Frontiers in medicine
|October 23, 2024
概括
极端体重指数 (BMI) 与28天败血症死亡率有关. 体重不足的败血症患者面临更高的死亡风险,而超重和肥胖患者的风险降低,观察到性别特定的模式.
科学领域:
- 关键护理医学 关键护理医学
- 临床流行病学临床流行病学
- 败血症的研究研究.
背景情况:
- 败血症是一种危及生命的疾病,死亡率很高.
- 体质指数 (BMI) 在败血症结果中的作用需要进一步阐明.
- 了解BMI与死亡率的关联可以为临床管理提供信息.
研究的目的:
- 调查体质指数 (BMI) 与败血症患者28天死亡率之间的相关性.
- 探索BMI与死亡率相关的性别特异性差异.
主要方法:
- 使用MIMIC-IV数据库 (V2.2) 的回顾性队列研究 (V2.2).
- 包括14,883名败血症患者,按BMI (体重不足,正常,超重,肥胖) 和性别分类.
- 主要结局是从ICU入院后的28天死亡率.
主要成果:
- 在BMI和28天死亡率 (p < 0.001) 之间观察到总体L形关系.
- 发现了显著的性别特异差异.
- 男人表现出U形的BMI-死亡率曲线 (p < 0.001),而女性表现出L形曲线 (p = 0.045).
结论:
- 极端的BMI与败血症患者的28天死亡率有关.
- 体重不足会增加死亡风险,而超重/肥胖可能会有保护作用.
- 在男性和女性败血症患者之间存在明显的BMI-死亡率模式.
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