在患有慢性乙型肝炎感染的母亲中,产后肝炎爆发
Shi OuYang1, Yawen Geng1,2, Gongqin Qiu1
1Department of Infectious Diseases, Key Laboratory of Biological Targeting Diagnosis, Therapy, and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P. R. China.
Gastroenterology report
|October 23, 2024
概括
产后阿兰氨基转移酶 (ALT) 爆发发生在25.7%的患有慢性乙型肝炎 (CHB) 的母亲身上. 风险因素包括HBV DNA水平和停止抗病毒治疗,指导新的管理策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 患有慢性乙型肝炎 (CHB) 的母亲产后氨酸转移酶 (ALT) 升高是一个临床挑战,文献不一致.
- 针对母婴传播的抗病毒预防和产后治疗停止,使孕妇B型肝炎病毒 (HBV) 感染的管理复杂化.
研究的目的:
- 审查和分析产后ALT爆发在患有CHB的母亲的数据.
- 为了确定产后ALT升高的发病率,严重程度和危险因素.
- 为产后ALT爆发提出一个风险分层管理算法.
主要方法:
- 对PubMed,CNKI和万芳数据库的文献综述 (2000年1月至2023年12月).
- 包括23项研究,涉及8077名孕妇.
- 对发病率,严重程度和风险因素的综合分析.
主要成果:
- 产后ALT升高的总体发病率:25.7% (轻度),4.4% (中度),1.7% (严重).
- 在接受预防的HBeAg阳性母亲中,发病率为5.9% (中级) 和0.8% (严重),没有死亡率或肝移植.
- 确定了关键的风险因素:HBV DNA水平,产前ALT,产后抗病毒停止和HBeAg状态.
结论:
- 患有CHB的母亲中有很大一部分经历了产后ALT升高,主要是轻微的.
- 风险因素是可以识别的,允许风险分层.
- 一个拟议的算法可以指导治疗新和经验丰富的人群的临床管理,以改善结果.
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