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获得等待名单和移植后结果的患者与未成功的移植二次性复发性淋巴结膜炎
Ryan Gately1, Germaine Wong2,3,4, Armando Teixeira-Pinto2,3
1Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Transplantation direct
|October 23, 2024
概括
复发性淋巴细胞突炎 (GN) 并没有使脏移植接受者在再移植后的等待列表或异体移植存活率方面处于不利地位. 然而,超过20%的患者由于复发性GN而失去首次移植,同时也因同一种疾病而失去第二次移植.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 临床流行病学临床流行病学
背景情况:
- 复发性淋巴结膜炎 (GN) 是移植损失的重要原因之一.
- 由于复发性GN导致的全移植失败后的再移植需要仔细评估.
- 了解结果对于管理NGG末期病患者至关重要.
研究的目的:
- 评估在失去第一个合移植到复发性GN.之后重新被列入移植的概率.
- 评估第二次移植后全移植损失的风险,在有复发性GN病史的患者中进行.
主要方法:
- 利用了来自澳大利亚和新西兰透析和移植注册表的数据.
- 采用多变量考克斯模型来比较结果.
- 分析了先前有或没有复发性GN的患者等候名单的概率和全移植损失风险.
主要成果:
- 在3276名第二次脏移植接受者中,5%的接受者因为复发性GN而失去了他们的第一个全移植.
- 之前有复发性GN的患者在重复移植后具有可比的等待列表潜力 (aHR 1.16) 和全移植损失风险 (aHR 1.02).
- 在GN复发后重新移植的患者中,22%的患者因复发性疾病而失去第二次全移植.
结论:
- 由于复发性GN而导致的先前的全移植损失似乎不会使患者在随后的移植中处于不利地位.
- 等候名单潜力和整体移植结果对于重复移植是可比的.
- 很大一部分患有复发性GN的患者可能会因为相同的情况而失去随后的全移植.
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