在未破裂的内动脉瘤患者中,神经心理功能,大脑结构和大脑输液的异常变化
Wei Li1, Si Zhang1, Weijie Fan1
1Xinqiao Hospital, Chongqing, China.
Frontiers in neurology
|October 23, 2024
概括
未破裂的内动脉瘤 (UIA) 与情绪和认知问题有关. 微妙的脑部变化,包括灰质和血液流量减少,可能解释UIA患者的这些损伤.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 未破裂的内动脉瘤 (UIA) 与情绪和认知缺陷有关.
- 这些障碍的潜在神经生物学机制尚不清楚.
研究的目的:
- 用VBM和SBM来研究UIA患者的结构性大脑变化.
- 探索大脑形态,大脑血液 perfusion 和神经心理结果之间的相关性.
主要方法:
- 使用基于voxel的形态测量 (VBM) 和基于表面的形态测量 (SBM).
- 49名UIA患者和50名健康对照人群之间的结构变化进行了比较.
- 分析了皮层形态,血液输液和神经心理测试结果.
主要成果:
- 在UIA患者中,右前轨道前皮层的灰质增加.
- 在左丘脑脉动体和海马体中观察到灰质的减少.
- 在右侧的中后回形和内皮层中,下部碎形维度,脑输液减少与灰质损失和执行功能受损相关.
结论:
- 患有UIA的患者会经历认知障碍和情绪失调.
- 灰质体积,碎形尺寸和脑血流的微妙变化与这些缺陷有关.
- 研究结果为UIA认知障碍的机制提供了洞察力.
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