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重复的次脑震荡导致神经活动中断,独立于脑震荡史

Kevin Grant Solar¹, Matthew Ventresca¹, Rouzbeh Zamyadi¹

¹Neurosciences and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 0A4.

Brain communications

|October 23, 2024

概括

在体育和军事中常见的重复性次脑震荡会损害大脑功能,导致神经系统缺陷. 磁脑电图可以检测到这些变化,有助于预防和治疗累积神经创伤.

科学领域:

神经科学是一个神经科学.
公共卫生公共卫生
军事医学军事医学

背景情况:

脑震荡和次脑震荡对公共健康构成重大风险,重复的次脑震荡可能导致严重的神经缺陷.
慢性创伤性脑病变 (CTE) 与脑震荡前史有关,突出显示了对体内生物标志物的需要.
在军事和接触体育运动中,职业爆炸过压是重复性次震荡暴露的常见来源.

研究的目的:

研究重复性次脑震荡对神经元活动和功能连接性的影响.
评估不同爆炸暴露水平的军事样本中神经症状和心理健康.
探索磁脑电图 (MEG) 和功能性MRI (fMRI) 在识别子脑震荡神经创伤的生物标志物的实用性.

主要方法:

一项涉及81名军事人员的横截面研究,根据一般化爆炸暴露值分为高和低爆炸暴露组.
使用磁脑电图 (MEG) 来测量神经元活动和功能连接.
使用功能性MRI (fMRI) 来评估功能连接,与39名参与者的子集.

主要成果:

在高爆炸暴露群体中,MEG揭示了神经活动的破坏,包括右前叶和皮层下区域的神经减速 (增加的三角形活动).
在后置默认模式网络中通过MEG观察到功能性失联 (低玛和高玛连接性下降).
较高的爆炸暴露与较差的体质和认知结果相关,独立于脑震荡或创伤性压力史.

结论:

重复的次脑震荡对大脑功能有不利影响,表现为神经元活动和连接性的改变.
磁脑电图是一种敏感的工具,用于检测次震荡性神经创伤,为识别受影响的大脑区域和有风险的人提供了潜在的潜力.
研究结果表明,MEG可以作为一种有价值的工具,用于早期检测,治疗目标和预防累积性脑震荡下神经创伤的预防策略.

关键词:

三角洲振荡的三角洲振荡.电生理学成像检测电生理学成像马振荡的马振荡神经退行症的神经退行症知道的知道的知道的

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