治疗后通过综合黄素和多克索鲁比改性基UiO-66 MOFs使用抗氧化剂和抗癌治疗策略
Chao-Jan Liu1, Jung-Hua Lin1, Man-Tzu Li2
1Department of Science Education, National Taipei University of Education, No. 134, Sect. 2, Heping E. Rd., Da'an District, Taipei City 106, Taiwan. kclee@tea.ntue.edu.tw.
Journal of materials chemistry. B
|October 23, 2024
概括
这项研究引入了一种新的双重药物递送系统,使用改性金属有机框架 (MOF) 来递送多克索鲁比和黄素,有效地抑制瘤生长和复发,增强抗氧化特性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 传统化疗面临着瘤复发的挑战.
- 开发新的药物输送系统对于有效的癌症治疗至关重要.
- 金属有机框架 (MOF) 为先进的药物输送应用提供了潜力.
研究的目的:
- 设计一种使用替代Uio-66 MOF的双重药物递送系统.
- 封装多克索鲁比辛和黄素,以增强抗癌活性和减少复发.
- 研究开发系统的抗氧化和抗瘤特性.
主要方法:
- 用修改Uio-66 MOF以提高抗氧化能力.
- 使用pyrene修饰的氨酸作为自组装和药物封装的连接器.
- 同时提供多克索鲁比辛和黄素,以获得协同作用的抗癌效应.
- 在体外抗氧化剂测定 (自由基清除) 和结肠癌细胞系中的抗瘤活性评估.
- 在Xenograft裸体小鼠模型中进行体外药物释放研究和体内疗效评估.
主要成果:
- 设计的MOF系统显示出显著的抗氧化能力.
- 在人类结肠癌细胞系中观察到增强的抗瘤活性.
- 该系统表现出缓释动力学和对酸反应药物释放.
- 在体内研究表明,尽管药物含量较低,但与自由多克索鲁比辛相比,瘤抑制能力相当.
- 该系统提供了强大的抗癌效率,增强了抗氧化能力.
结论:
- 双重药物输送系统在缓解瘤复发和增强癌症治疗方面表现有前途.
- 用替代的MOF平台为同时进行双重药物递送提供了一种新的方法.
- 这一策略有可能促进临床癌症治疗和预防的发展.
更多相关视频
09:46Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
8.9K
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:46Electron Transport Chain: Complex I and II
12.0K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.0K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K