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对盐有反应的肠道微生物群诱导性别特异性血压变化
Pritam Bardhan1, Xue Mei1,2, Ngoc Khanh Lai1
1Department of Physiology and Pharmacology, Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, OH (P.B., X.M., N.K.L., B.M., R.T., S.A., I.M., H.H., T.A.J., R.R.A., J.K., B.J., T.Y.).
Circulation research
|October 23, 2024
概括
肠道微生物群和酸盐代谢对男性和女性的血压有不同的影响. 盐的摄入加剧了接受雄性肠道微生物的雌性大鼠的高血压,突出了血压调节中的性别特异性作用.
科学领域:
- 微生物学 微生物学
- 生理学 生理学 生理学
- 遗传学 遗传学 是一个
背景情况:
- 氨酸代谢,特别是氨酸-醇通路,对于血压调节至关重要,并由肠道微生物群介导.
- ангиотензин转化酶2 (ACE2) 影响托的吸收和肠道微生物群的组成,而ACE2缺乏会改变微生物群落.
- 肠道微生物群的性别差异是已知的,但它们通过托-英多尔通路对血压的影响仍然不清楚.
研究的目的:
- 为了研究肠道微生物群介导的酸-英多尔通路影响高血压的性别特异性机制.
- 建立一种新的老鼠模型来研究这些性别特异性影响.
主要方法:
- 使用CRISPR-Cas9生成了一种新的老鼠模型,以删除Dahl盐敏感老鼠中的Ace2.
- 从两性捐赠者向女性接受者进行的内微生物群转移.
- 通过口服给两性老鼠注射,以评估血压反应.
主要成果:
- 与男性肠道微生物群相比,女性肠道微生物群对二,Ace2缺乏和盐的抵抗力更强.
- 接受雄性细胞微生物群的雌性大鼠在对盐的反应中表现出更大的血压升高.
- 在男性中引起血压升高,但在女性中并非如此;盐改变了宿主酸盐的新陈代谢,在女性中降低了血清素,增加了金氨酸衍生物.
结论:
- 在肠道微生物群中介的三甲代谢中,一种新的性别特异性机制影响了血压调节.
- 盐对宿主肠道微生物群的托代谢有不同的影响,取决于性别.
- 肠道微生物群及其新陈代谢在盐敏感高血压的发展中扮演着不同的性别特异性的角色.
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