针对的局部,基于光的和补充性干预措施:系统审查的概述
Yi Yuan1, Yiying Wang1, Jun Xia2
1Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
The Cochrane database of systematic reviews
|October 23, 2024
概括
这次审查发现了非常低的确定性证据,表明氧化可以减少病变,但与局部视网或抗生素相比,其益处很小. 对治疗的高质量证据仍然有限.
科学领域:
- 皮肤病学 皮肤病学
- 证据综合 证据综合
- 药理学 药理学是指药理学的学科.
背景情况:
- 是一种常见的慢性炎症性皮肤疾病,影响着pilosebaceous单元.
- 它呈现出非炎症和炎症性病变,影响生活质量和心理健康.
- 在全球范围内越来越普遍,并可能导致诸如痕等并发症.
研究的目的:
- 综合关于非系统性药理和非药理干预措施对的有效性和安全性的证据.
- 评估的治疗方法和相关的皮肤并发症,如痕.
主要方法:
- 在2021年12月之前搜索了多个数据库 (Cochrane,Epistemonikos,MEDLINE,Embase)
- 包括具有低偏差风险的系统审查 (ROBIS工具) 和使用GRADE评估的证据确定性.
- 从六项符合条件的审查中提取了数据,涵盖了40910名参与者的和1316名参与者的痕.
主要成果:
- 氧化显示了非常低的确定性证据,可以减少病变数量与安慰剂相比,有可能增加不良事件.
- 对于大多数结果,氧化与阿达巴林 (局部视网) 或克林达米辛 (局部抗生素) 相比几乎没有差异.
- 对氧化与局部视网类药物和抗生素的证据通常具有非常低至低的确定性,对特定比较和生活质量等结果的数据有限.
结论:
- 没有发现任何局部治疗,光疗或或痕补充疗法的高确定性证据.
- 包含的试验和系统审查的方法质量的限制阻碍了最终的结论.
- 未来的研究应该集中在对新兴药物和并发症的综合分析上,解决局部类药物和抗生素缺乏高质量的证据的问题.
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