吸烟与鼻癌风险之间的关联:一个元分析
I Possenti1, A Martini1, V Bagnardi2
1Department of Medical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Rhinology
|October 23, 2024
概括
吸烟显著增加了鼻癌 (NPC) 的风险,目前和曾经吸烟者的风险更高. 风险因NPC亚型而异,强调了不同的预防需求.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 鼻癌 (NPC) 是一种在东亚和东南亚普遍存在的侵略性恶性瘤.
- 了解吸烟与NPC风险之间的联系对于公共卫生倡议至关重要.
研究的目的:
- 量化吸烟与NPC风险之间的关联.
- 通过组织学亚型,吸烟状态,强度,持续时间和戒烟时间来分析风险.
主要方法:
- 在2023年5月之前对病例控制和队列研究进行系统审查和元分析.
- 包括46篇符合条件的文章中的40项原始研究.
- 估计各种吸烟指标的相对风险 (RR).
主要成果:
- 与从未吸烟者相比,目前吸烟者的RR为1.61,前吸烟者的RR为1.28,一直吸烟者的RR为1.62.
- 曾经吸烟的人对状细胞NPC (2.37) 的RR较高,而非分化NPC (1.06).
- 随着吸烟的强度和持续时间,NPC风险增加,并且随着戒烟的时间而降低.
结论:
- 证实烟草吸烟和NPC之间存在显著的关联.
- 突出了即使是中度吸烟的风险增加和NPC亚型的差异性风险.
- 根据吸烟习惯和NPC组织学,为针对性的NPC预防策略提供信息.
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