颗粒大小对Codonopsis pilosula中不同化学成分溶解的影响
Shuteng Huang1, Hanxiu Deng1, Xue Zhao2
1Binzhou Medical University, Yantai, China.
Biomedical chromatography : BMC
|October 23, 2024
概括
与蒸片 (CP-DP) 相比,具有较小颗粒大小的Codonopsis pilosula沸粉 (CP-BP) 增强了化学成分的溶解. 这种差异对于通过PI3K-Akt.等途径治疗免疫抑制是显著的.
科学领域:
- 草药是一种草药.
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- 科多诺普西斯 (法语:Codonopsis pilosula) 是一种植物. 没有Nannf. 是一种用于免疫抑制的传统草药.
- 科多诺普西斯 (Codonopsis pilosula) 沸粉 (CP-BP) 使用来自脱碎片 (CP-DP) 的较小颗粒.
- 微粒大小对C. pilosula脱过程中化学成分溶解的影响尚不清楚.
研究的目的:
- 描述和比较CP-BP和CP-DP中的化学成分.
- 为了研究颗粒大小对成分溶解和含量的影响.
- 探索这些变化在治疗免疫抑制方面的潜在治疗意义.
主要方法:
- 超高性能液体染色学四极-精确轨道质谱仪 (UHPLC-QE Orbitrap MS) 用于组件分析.
- 用相对峰值面积,提取率和酒精溶解率来评估成分含量.
- 网络药理学和分子对接被用来预测治疗途径和目标相互作用.
主要成果:
- 在这两种中共发现了71种化合物.
- 一般来说,CP-BP脱的确定的化合物含量高于CP-DP脱.
- 由于颗粒大小的变化,类的含量显示出最显著的变化,而类的平均含量最高.
结论:
- 与CP-DP相比,CP-BP中较小的颗粒大小提高了C. pilosula组件的溶解.
- 氨基酸3-激酶 (PI3K) -Akt通路是C. pilosula在治疗免疫抑制方面的潜在目标.
- 具有显著含量变化的化合物与EGFR,PTGS2和PPARG等关键点具有良好的对接亲和力,这表明它具有实际的治疗意义.
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