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在中风后焦虑中使用素的安全性和有效性 - - 一项试点前性随机开放盲目的终点 (PROBE) 研究

Satish Barki¹, Deepti Vibha¹, Sudhir Pachipala¹

¹Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

International journal of psychiatry in medicine

|October 23, 2024

概括

与治疗中风后轻度焦虑症的标准治疗相比,素没有显著的差异. 对于患有更严重焦虑症的患者,需要进一步的研究.

科学领域:

神经学神经学
精神病学是一个精神病学.
临床试验临床试验

背景情况:

脑卒中后焦虑症 (PSA) 影响了20%-25%的患者.
在PSA中抗抑郁药疗效的证据有限.
这项研究评估了PSA的fluoxetine.

研究的目的:

评估素在治疗中风后焦虑症中的安全性和有效性.
为了比较fluoxetine对标准医疗保健的影响.

主要方法:

一个前性随机开放盲目的终点 (PROBE) 试点研究.
60名中风后患者被随机分配给素 (20毫克/天12周) 或标准治疗.
主要结局:汉密尔顿焦虑评分表 (HAM-A) 在12周改善.

主要成果:

参与者的PSA总体患病率为50.8%.
在12周内,在fluoxetine和对照组之间的HAM-A改善没有显著差异 (P=0.91).
在二次结果 (mRS,BI,SF-36,HAM-D) 或不良事件中没有显著差异.

结论:

富洛素和标准护理在12周后在轻微的PSA中产生了可比的改善.
需要对严重PSA的药理疗法进行进一步的研究.

关键词:

汉密尔顿焦虑评级尺度的焦虑评级尺度.克塞提因 (fluoxetine) 是一种含有素的药物.在中风后的焦虑症.这是一项前性随机开放盲目的终点研究 (PROBE).

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