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使用合理合成的CDR和具有高摩尔吸收性的奇拉分子进行活性药物成分的LC enantioseparation

Sonika Sethi¹, Ravi Bhushan²

¹School of Engineering and Sciences, GD Goenka University, Sohna Road, Gurugram (Gurgaon), Haryana, India.

Biomedical chromatography : BMC

|October 23, 2024

概括

本综述详细介绍了用于定异构纯度的奇拉衍生试剂 (CDR) 的合成和应用. 这些方法提供了有效的种族分离,对药物开发至关重要.

科学领域:

基质化学基质化学基质化学基质化学
分析化学是一种分析化学.
有机合成有机合成

背景情况:

光学活性化合物需要精确确定反体过量 (ee),反体比 (er) 和反体纯度.
对于活性药物成分 (API) 和其他有价值的种族物质来说,分离异构体至关重要.

研究的目的:

审查各种手性衍生试剂 (CDR) 的理性合成.
突出这些CDRs在分离和隔离不同种族物质中的反体的成功应用.
讨论用于反分离的创新方法及其在确保药物化合物的纯度方面的实际用途.

主要方法:

合成CDRs使用化纯胺,化辅助剂 (二二丁二,化), (S) - 基托, (S) - 利沃弗洛克萨,和异酸盐.
采用"绿色"反相高性能液态染色法 (RP-HPLC) 方法,使用水微粒移动相.
使用简单的Achiral衍生物与ninhydrin用于反体纯度的评估.

主要成果:

使用合成的CDRs证明了各种赛马的成功分离.
展示了染色体试剂成分的"脱标"以获得原生反体.
突出了这些基于CDR的方法的优势,而不是商业化相用于确定和控制质纯度.

结论:

经过审查的CDR合成和应用方法提供了有效的策略来实现enantioseparation.
这些方法为控制和保证制药化合物的反体纯度提供了实际解决方案.
描述的方法在效率和适用性方面具有优势,相比于现有的商业化拉性阶段.

关键词:

药品中的活性药物成分.奇拉衍生试剂奇拉衍生试剂在对抗分离的过程中.液体色谱学液体色谱学液体色谱学

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