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在RUNX3-甲基化扩散食道胃结瘤中,FOXP3+/CD8+比率与攻击性行为相关

Suguru Maruyama¹, Yu Imamura¹, Tasuku Toihata²

¹Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

|October 23, 2024

概括

调节性T细胞 (Tregs) 和CD8+细胞影响癌症免疫力. 在侵袭性胃食道腺癌中,高FOXP3+/CD8+比率表明预后不佳和潜在的免疫逃脱,特别是在扩散亚型中.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

瘤免疫微环境对于积极的癌症治疗至关重要.
调控性T细胞 (Tregs) 可以抑制由CD8+T细胞介导的抗瘤免疫反应.

研究的目的:

调查Treg (FOXP3+) 和CD8+细胞比例在扩散性,非EBV/非MSI高的胃食道腺癌 (GEA) 中的预后意义.
探索FOXP3+/CD8+比率,瘤组织学,RUNX3甲基化和患者存活率之间的关系.

主要方法:

使用数字图像分析对303种化疗无效食管胃结 (EGJ) 腺癌的FOXP3+/CD8+细胞比例进行定量分析.
与瘤组织学 (扩散与肠道),RUNX3甲基化状态和癌症特异性5年生存率的相关性分析.
从癌症基因组图谱 (TCGA) 中整合了多组学数据.

主要成果:

侵入性边缘高FOXP3+/CD8+比率与扩散EGJ腺癌的预后不佳有关,特别是在I-III阶段的瘤中.
根据瘤组织学,FOXP3+/CD8+比率的预后影响有显著差异.
高FOXP3+/CD8+比与RUNX3甲基化相关,并预测RUNX3甲基化扩散亚型的存活率较低.
CCL28与RUNX3抑制的扩散GEA亚型有关.

结论:

侵袭边缘的FOXP3+/CD8+比率是非EBV/非MSI高EGJ腺癌的显著预后生物标志物.
较高的比率表明潜在的瘤免疫逃脱,特别是在RUNX3-甲基化扩散亚型中,可能由CCL28.2介导.

关键词:

这是一种化学物质,chemokine.扩散的组织学.效应细胞T细胞的效应细胞.消化管胃结腺癌腺癌.监管性T细胞监管性T细胞

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