金属的可用性塑造了生命早期的微生物生态和社区继承
Joshua Soto Ocaña1,2, Elliot S Friedman3, Orlaith Keenan1,2
1Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
mBio
|October 23, 2024
概括
金属的可用性,受婴儿养类型的影响,塑造了肠道微生物群.
科学领域:
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
- 营养免疫学 营养免疫学
背景情况:
- 肠道微生物群对人类健康至关重要,早期生活殖民影响免疫发育和以后的健康结果.
- 主体的营养免疫力和金属的可用性是生命早期微生物社区聚集的未被充分研究的因素.
- 婴儿肠道微生物群的发展是建立终身健康模式的关键窗口.
研究的目的:
- 调查宿主介导的营养免疫和金属可用性在塑造婴儿肠道微生物社区组合中的作用.
- 探索养方式 (母乳养与配方养) 如何影响婴儿的金属含量和随后的微生物组成.
主要方法:
- 对人类婴儿队列的分析,包括对金属化蛋白calprotectin的测量.
- 在体外实验中评估关键早期殖民肠道细菌的金属耐药性.
- 在母乳养和配方奶粉养的婴儿之间比较肠道金属含量和微生物群落.
主要成果:
- 金属化蛋白calprotectin在婴儿中非常丰富.
- 成功的早期肠道殖民者 (例如,菌,细菌) 显示对金属饥饿的抵抗力,而乳杆菌则易受影响.
- 与母乳养的婴儿相比,配方奶粉养的婴儿的肠道金属含量更高,并且具有独特的微生物群落,这些微生物群落丰富于耐金属类型.
结论:
- 受到宿主营养免疫力和养类型的影响的金属可用性是早期肠道微生物群聚集的重要因素.
- 主体介导的金属限制可以塑造早期殖民肠道细菌的健康状况.
- 饮食中的金属是婴儿肠道微生物组建立的关键因素,以前没有受到重视.
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