导航乳腺癌的治疗场景:准乳腺癌干细胞
Soudeep Dey1, Yirivinti Hayagreeva Dinakar2, Soundarya R2
1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570015, India.
Naunyn-Schmiedeberg's archives of pharmacology
|October 23, 2024
概括
针对乳腺癌干细胞 (BCSCs) 对于有效治疗至关重要. 本综述涵盖了包括纳米技术和CAR T细胞疗法在内的新策略,以克服耐药性和预防乳腺癌复发.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
背景情况:
- 乳腺癌仍然是一个重大的全球健康挑战,乳腺癌干细胞 (BCSCs) 推动瘤发生,转移和复发.
- 传统疗法经常无法根除BCSCs,导致治疗耐药性和疾病复发.
研究的目的:
- 为新兴的治疗策略提供全面的概述,专门设计以向乳腺癌干细胞 (BCSCs).
- 探索纳米技术和先进疗法的应用,以克服BCSC介导的治疗耐药性.
主要方法:
- 对针对BCSCs的治疗策略的当前文献的审查,包括信号通路抑制,受体向,化疗,植物药物和纳米技术.
- 对纳米载体系统 (聚合物,脂质,金属基) 的分析,用于针对性地输送治疗剂 (药物,siRNA,基因编辑工具).
- 探索先进的方法,如仿真抗原受体 (CAR) T 细胞疗法,切除疗法和无细胞疗法.
主要成果:
- 纳米技术提供了精确的治疗方法,并减少了副作用,有效地准与BCSC相关的途径和蛋白质.
- 刺激响应和受体向的纳米载体显示出增强的治疗疗效.
- 像CAR T细胞疗法这样的新兴策略显示出直接准和消除BCSCs的希望.
结论:
- 准BCSC对于改善乳腺癌治疗结果和预防复发至关重要.
- 纳米技术和先进的细胞疗法代表了开发更有效的BCSCC导向治疗的有希望的途径.
- 需要结合传统和新策略的多方面的方法,以全面解决BCSC驱动的乳腺癌.
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