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在ANCA相关的血管炎中与甲状腺疾病的临床关联
Zhihuan Zhang1, Wenhan Huang1, Feifeng Ren1
1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing, 400010, China.
Clinical rheumatology
|October 23, 2024
概括
与抗中性细胞质抗体 (ANCA) 相关的血管炎患者的甲状腺疾病发病率较高. 女性性别,冠状动脉疾病和抗Ro/SSA抗体与这些患者的甲状腺问题有关.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 反中性细胞质抗体 (ANCA) 相关的血管炎 (AAV) 是一组系统性自身免疫性疾病.
- 甲状腺功能障碍是一些自身免疫性疾病中已知的关节外表现.
- 在AAV和甲状腺疾病之间的特定关系需要进一步阐明.
研究的目的:
- 为了确定诊断为AAV的患者甲状腺疾病的频率.
- 调查AAV患者甲状腺疾病的临床相关性和相关因素.
主要方法:
- 对305名AAV患者进行了回顾性分析.
- 收集和比较了人口,临床和实验室数据.
- 单变量和多变量逻辑回归模型确定了与甲状腺疾病相关的因素.
主要成果:
- 相当一部分AAV患者 (17.0%) 同时出现甲状腺疾病.
- 与甲状腺疾病相关的因素包括女性性别,冠状动脉疾病和阳性抗Ro/SSA抗体.
- 统一分析还强调了与抗Ro52,抗甲状腺蛋白抗体 (TgAb) 和抗甲状腺过氧化酶抗体 (TPOAb) 的关联.
结论:
- 在AAV患者中,甲状腺疾病的发病率较高.
- 建议对AAV患者进行常规的甲状腺功能监测.
- 特定的患者亚组,包括女性和患有冠状动脉疾病或抗Ro/SSA抗体的患者,需要特别注意.
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