系统性血压多基因风险评分与甲基反应的实用性
Nicole D Armstrong1, Vinodh Srinivasasainagendra2, Amit Patki2
1Department of Epidemiology, University of Alabama at Birmingham.
JAMA cardiology
|October 23, 2024
概括
系统性血压 (SBP) 的多原风险评分 (PRS) 预测了黑人高血压患者对甲的反应,而不是利西诺普里尔. 较高的SBP PRS与明显抗治疗高血压的几率增加有关.
科学领域:
- 药物基因组学 药物基因组学
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
背景情况:
- 多基因风险评分 (PRS) 对预测血压 (BP) 对抗高血压治疗 (AHT) 的反应的临床实用性仍然不清楚.
- 高血压 (HTN) 影响数百万人,需要个性化治疗策略.
研究的目的:
- 调查系统性BP (SBP) PRS对AHT反应和明显的耐治疗高血压 (aTRH) 的预测能力.
主要方法:
- 分析了来自高血压相关治疗遗传学 (GenHAT) 研究的黑人参与者的子集,这些参与者被随机分配到chlorthalidone或lisinopril.
- 系统性血压PRS被分为五分之一,并使用多变量回归来检查其与血压变化和6个月的aTRH的关联.
主要成果:
- 每增加SBP PRS的五分位数都与降低对chlorthalidone的BP反应有关.
- 与中等五分位数相比,SBP PRS五分位数最高的参与者患有aTRH的几率比中等五分位数高67%.
- 没有观察到SBP PRS和BP对lysinopril的反应之间的显著关联.
结论:
- 血压升高的较低遗传风险 (较低的SBP PRS) 与黑人个体对甲的更高血压反应有关.
- SBP PRS可能会识别患有HTN的个体具有更高的治疗耐药性风险.
- SBP PRS显示了在高血压中引导甲治疗选择的潜力.
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