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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.6K
Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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相关实验视频

Updated: Jun 9, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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定量全基因模型发现可解释的全基因组关联.

Natália Ružičková1, Michal Hledík1, Gašper Tkačik1

  • 1Institute of Science and Technology Austria, Klosterneuburg AT-3400, Austria.

Proceedings of the National Academy of Sciences of the United States of America
|October 23, 2024
PubMed
概括

量化全基因模型 (QOM) 通过将监管网络与基因组数据集成来解释复杂的特征. 这种方法改善了基因表达预测,并比传统方法更有效地识别因果途径.

科学领域:

  • 遗传学和基因组学 遗传学和基因组学
  • 系统生物学 系统生物学
  • 统计建模 统计建模

背景情况:

  • 全基因组关联研究 (GWAS) 识别了复杂特征的众多位点,每个位点都解释了小的差异分数.
  • 全基因模型建议通过监管网络的传播来促进遥远的位置.
  • 现有的模型很难将网络拓与基因组数据集成到复杂的特征分析中.

研究的目的:

  • 将万能模型正式化为统计框架:定量万能模型 (QOM).
  • 通过监管网络改善基因表达预测和理解特征遗传性.
  • 评估转录和非转录效应在复杂特征中的作用.

主要方法:

  • 开发了量化全基因模型 (QOM),将监管网络拓与基因组数据集成在一起.
  • 应用QOM对酵母中的基因表达特征.
  • 估计的cis-和trans-可遗传变异,以及效应传播顺序.

主要成果:

  • QOM实现了与GWAS相比较的基因表达预测,参数显著减少.
  • QOM确定了通过监管网络传播效应的候选因果链.
  • QOM准确地解释了基因表达共变性结构,并将转录和非转录效应区分开来.
关键词:
基因监管网络 基因监管网络全基因组关联研究研究.网络 网络 网络 网络 网络 网络这就是"万能基因模型".酵母酵母是一种酵母.

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Infinium Assay for Large-scale SNP Genotyping Applications
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Infinium Assay for Large-scale SNP Genotyping Applications

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

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相关实验视频

Last Updated: Jun 9, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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Infinium Assay for Large-scale SNP Genotyping Applications
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Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

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结论:

  • 通过结合监管网络信息,QOM提供了一个强大的统计框架来分析复杂的特征.
  • 该模型提高了遗传效应的预测准确性和生物解释性.
  • QOM与系统生物学,网络质量评估以及理解多种效应传播有关.