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相关概念视频

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

134
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
134
Overview of Synapses01:25

Overview of Synapses

2.2K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the...
2.2K
Understanding Sleep01:11

Understanding Sleep

220
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
220
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
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相关实验视频

Updated: Jun 9, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
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Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

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正在发展的前脑突触特别容易受到睡眠丧失的影响.

Sean M Gay1, Elissavet Chartampila1, Julia S Lord1

  • 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Proceedings of the National Academy of Sciences of the United States of America
|October 23, 2024
PubMed
概括

缺乏睡眠会比成年人大脑更严重地损害发育中的大脑,影响认知功能和突触发育. 青少年的这种脆弱性可能与自闭症谱系障碍 (ASD) 风险有关.

关键词:
发展发展发展发展发展.基蛋白质组 (Phosphoproteome) 是一种基蛋白质组.蛋白质组是蛋白质组的组成部分.睡眠 睡眠 睡眠 睡眠 睡眠突触突触突触是一个突触突触.

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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
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Noninvasive, High-throughput Determination of Sleep Duration in Rodents

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相关实验视频

Last Updated: Jun 9, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.0K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
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Noninvasive, High-throughput Determination of Sleep Duration in Rodents

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 睡眠科学 睡眠科学

背景情况:

  • 睡眠对整个生命中大脑健康和认知至关重要.
  • 突触是睡眠恢复功能的关键目标,并受到睡眠剥夺 (SD) 的影响.
  • 睡眠在突触功能中的作用在发育和成年之间有所不同,这对诸如自闭症谱系障碍 (ASD) 等神经发育障碍有影响.

研究的目的:

  • 调查不同发育阶段 (青少年,青少年,成年人) 的睡眠和SD脆弱性机制的不同功能.
  • 为了比较P21-28,P42-49和P70-100的小鼠对急性SD的行为和分子反应.

主要方法:

  • 系统地检查对急性睡眠剥夺的行为和分子反应.
  • 使用了两性幼年,青少年和成年老鼠.
  • 采用亚细胞分离,蛋白质组和蛋白质组分析.

主要成果:

  • 青少年小鼠表现出认知缺陷,缺乏对SD的适应,与表现出性的成年人不同.
  • 发育中的突触对SD非常脆弱,在青少年中产生突触强化,突触生成和周神经网络表达的异常诱导.
  • 成人的突触显示出对SD的比较性.

结论:

  • 睡眠服务于不同的发育功能,发育中的突触对睡眠障碍具有独特的脆弱性.
  • 早期睡眠不足会严重影响大脑发育和突触成熟.
  • 发育中的突触可能是SD脆弱性和ASD遗传风险的融合点,为ASD易感性提供了洞察力.