在临床环境中预测LATE-NC的新标准:可能/可能的LATE和LANS
1Sanders-Brown Center on Aging, Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington, KY 40536, United States.
Journal of neuropathology and experimental neurology
|October 23, 2024
概括
痴呆症分类的新术语,包括边缘主导的与年龄相关的TDP-43脑病变 (LATE),正在发展. 本综述阐明了临床综合征,生物标志物和与衰老相关的TDP-43蛋白质病变的病理定义之间的区别.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 老年病的医生 老年病的医生
背景情况:
- 与衰老相关的TDP-43蛋白质病变是痴呆症的一个重要原因.
- 边缘主导的与年龄有关的TDP-43脑病变 (LATE) 和边缘主导的记忆神经退行综合征 (LANS) 是最近提出的分类.
- 晚期神经病理变化 (LATE-NC) 是目前诊断的黄金标准.
研究的目的:
- 审查和讨论痴呆症分类的新术语,特别是与衰老相关的TDP-43病理学.
- 强调需要明确区分临床,生物标志物和病理疾病概念.
- 评估LATE提出的标准的不断变化的临床实用性.
主要方法:
- 关于痴呆症和LATE/LANS分类的最近提案的文献综述.
- 分析临床综合征,分子生物标志物和病理学定义之间的区别.
- 对不断发展的生物标志物研究对临床诊断的影响进行讨论.
主要成果:
- 介绍了LATE和LANS新提出的临床标题.
- 强调了精确的术语的重要性,区分临床表现,生物标志物证据和病理确认.
- 预计"可能"和"可能"LATE的定义将随着生物标志物研究的进展而获得临床相关性.
结论:
- 不断变化的术语旨在更好地定义与衰老相关的TDP-43蛋白质病变.
- 临床综合征和病理实体之间的明确区分对于准确的诊断和研究至关重要.
- 对于神经病理诊断和基础研究,LATE-NC的术语在新的临床标准下保持不变.
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