外源性阿片类药物和人类内分泌系统:一个内分泌学会科学声明
Niki Karavitaki1,2,3, Jeffrey J Bettinger4, Nienke Biermasz5
1Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.
Endocrine reviews
|October 23, 2024
概括
吸食阿片类药物会影响内分泌系统,影响生殖和上腺功能以及骨健康. 需要进一步的研究来充分理解和管理这些阿片类药物诱导的内分泌后果.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 吸食阿片类药物和滥用阿片类药物是一个重大的全球健康挑战.
- 长期阿片类药物对内分泌系统的影响,特别是下丘脑-垂体轴和骨健康,需要进一步调查.
- 现有研究强调需要全面了解阿片类药物诱导的内分泌功能障碍.
研究的目的:
- 评估目前关于阿片类药物对淋巴腺和上腺功能的影响的研究.
- 评估阿片类药物对生长激素,益生素,血管压素和催产素分泌的影响.
- 审查与阿片类药物相关的骨代谢,骨矿物质密度和骨折风险的变化.
主要方法:
- 对现有研究数据进行全面的审查和评估.
- 对研究阿片类药物对荷尔蒙分泌的影响的研究分析.
- 评估有关阿片类药物诱导的骨代谢变化的证据.
主要成果:
- 阿片类药物诱导的低阴性是一种已知的副作用.
- 阿片类药物对下丘脑-垂体-上腺轴和潜在的上腺功能缺陷的影响的临床意义尚不清楚.
- 关于阿片类药物对GH,益生菌素,血管压素和催产素的影响存在不一致的发现;证据将阿片类药物与负面的骨健康结果联系起来.
结论:
- 吸食阿片类药物与显著的内分泌序列有关,包括低子腺体和潜在的上腺功能不全.
- 阿片类药物对骨代谢产生负面影响,增加骨折风险.
- 仍然存在大量的研究缺口,需要进一步调查以改善阿片类药物使用者的临床护理.
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