2010年至2019年间,前列腺癌诊断时的年龄和前列腺特异性抗原的趋势
Lukas Owens1, Ojas Brahme1, Roman Gulati1
1Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
JNCI cancer spectrum
|October 23, 2024
概括
延迟检测前列腺癌正在增加新的转移性病例. 诊断时中位数年龄和前列腺特异性抗原 (PSA) 水平的上升表明,延迟检测有助于这一趋势.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 最近的数据显示,从2010年到2019年,美国的新转移性前列腺癌发病率有所增加.
- 潜在的因素包括减少前列腺癌查和导致升级的先进成像技术.
研究的目的:
- 调查延迟检测与新发转移性前列腺癌的增加之间的联系.
- 分析诊断时患者人口统计和前列腺特异性抗原 (PSA) 水平的趋势.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 患者数据.
- 对人口老龄化进行控制,以分析诊断趋势.
- 随着时间的推移,检查了诊断时的平均年龄和PSA水平的变化.
- 在诊断时评估PSA水平的种族差异.
主要成果:
- 从2010年到2019年,诊断时的中位数年龄增加了1.4年 (95% CI: 1.3-1.5),中位数PSA水平增加了1.4 ng/mL (95% CI: 1.4-1.5).
- 在非西班牙裔黑人男性 (4.3 ng/mL) 与非西班牙裔白人男性 (3.0 ng/mL) 相比,PSA在诊断时的第75百分位数显著增加.
- 研究结果支持推迟检测有助于增加转移性前列腺癌的假设.
结论:
- 延迟检测前列腺癌似乎是一个重要的因素,导致观察到新发转移性疾病的增加.
- 诊断时PSA水平的种族差异凸显了查或诊断途径中的潜在不平等.
- 需要进一步的研究来解决这些趋势和前列腺癌检测差异.
更多相关视频
相关概念视频
01:20Disorders of the Male Reproductive System
342
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
342
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K