病会影响人类肠道微生物组的组成和功能
Wenjie Mu1,2, Pingping Ma1, Yugui Wang1
1State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730000, China.
The ISME journal
|October 23, 2024
概括
人类的虫病 (带虫感染) 显著改变了肠道微生物群,增加了多样性和Prevotella. 双杆菌物种的数量减少,并且在治疗后没有恢复,影响了肠道健康.
科学领域:
- 寄生虫学的寄生虫学
- 微生物组研究的研究.
- 人的肠道健康 人的肠道健康
背景情况:
- 由Taenia条虫引起的人类虫,是全球健康问题.
- 泰尼亚菌感染对宿主肠道微生物群的影响仍未得到充分研究.
- 虫可以生长得很大,并影响肠道微生态.
研究的目的:
- 分析患有Taenia asiatica感染的患者的肠道微生物组变化.
- 为了评估除虫治疗后的微生物变化.
- 了解感染期间微生物组变化背后的机制.
主要方法:
- 在感染患者 (n=87) 和健康对照人群 (n=79) 中对肠道微生物群的截面研究.
- 在一个子集 (n=24) 中,长度评估除虫后的微生物变化.
- 使用了代谢网络分析,体外实验和机器学习.
主要成果:
- 泰尼亚感染导致肠道微生物α多样性增加和Prevotella驱动的肠类型.
- 感染个体的Bifidobacterium物种显著减少,并且在治疗后没有恢复.
- 脱虫后的微生物转移显示出高度的个体变异性;双杆菌的枯竭与代谢竞争有关,而不是直接的寄生虫.
结论:
- 病严重影响人类肠道微生物组的组成和多样性.
- 双杆菌的枯竭是病的一个关键特征,可能是由于微生物之间的竞争导致的,这种竞争是为了获得像葡萄糖这样的营养素.
- 肠道微生物组的变化可能在除虫后不会完全逆转,这突出了长期的健康影响.
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